What Happens if You Take Too Much Ozempic?

What Happens if You Take Too Much Ozempic

Taking medications as prescribed is crucial for effective treatment, especially when it comes to managing diabetes with Ozempic. However, there are potential risks associated with taking too much Ozempic. In this guide, we will break down Ozempic, its uses, dosage instructions, and what happens if you exceed the recommended amount.

Let’s navigate the world of Ozempic together to ensure a safe and well-informed journey.

What is Ozempic?

Ozempic, also known as semaglutide, is a diabetes medication created by Novo Nordisk. It is approved by the US Food and Drug Administration (FDA) to lower blood sugar in individuals with type 2 diabetes and reduce the risk of cardiovascular events in adults with established heart disease.

Key Components of Ozempic

Ozempic operates as a glucagon-like peptide 1 receptor agonist (GLP-1 receptor agonist). The active ingredient, semaglutide, stimulates insulin secretion and lowers glucagon secretion, aiding in blood sugar control based on glucose levels.

  • Active Ingredient: Semaglutide
  • Drug Class: Glucagon-like peptide 1 receptor agonist (GLP-1 receptor agonist)
  • Manufacturer: Novo Nordisk
  • FDA Approval: Lower blood sugar in type 2 diabetes, reduce cardiovascular risk in adults with type 2 diabetes and established heart disease

Different Ozempic Dosages Explained

Ozempic is available in injection form through single-patient-use pens, delivering 0.25 mg, 0.5 mg, or 1 mg per injection.

  • Ozempic Dosages
    • 0.25 mg per injection
    • 0.5 mg per injection
    • 1 mg per injection
  • Administration: Single-patient-use pens
  • Injection Frequency: Typically once per week
  • Prescribed by Healthcare Provider: Tailored to individual needs and medical history

How Ozempic Works?

As a GLP-1 receptor agonist, Ozempic binds to and activates GLP-1 receptors, leading to lower blood glucose levels. It stimulates insulin secretion and reduces glucagon secretion in a glucose-dependent manner. Additionally, Ozempic slightly delays the emptying of the stomach after meals, reducing the rate at which glucose circulates in the bloodstream.

How to Take Ozempic?

Ozempic is administered through subcutaneous injection using a pre-filled pen. It is a long-lasting medication, typically taken once a week. Your healthcare provider may prescribe Ozempic alongside insulin, and it’s crucial to follow their instructions carefully.

Do’s and Don’ts

  • Read the Instructions for Use provided with the pen.
  • Use Ozempic exactly as prescribed; do not exceed the prescribed amount.
  • Your healthcare provider will demonstrate how to use Ozempic before your first use.
  • Inject Ozempic under the skin of your stomach, thigh, or upper arm, avoiding muscles or veins.
  • Use Ozempic at the same time each week; you can adjust the day if the last dose was given 2 or more days before.
  • If you miss a dose, take it within 5 days; otherwise, skip it and resume the regular schedule.
  • Ozempic can be taken with or without food.
  • Do not mix insulin and Ozempic in the same injection; inject them in the same area but not right next to each other.
  • Rotate injection sites with each use.
  • Continue your diet and exercise program while on Ozempic.
  • Discuss with your healthcare professional how to manage low and high blood sugar.
  • Do not share Ozempic pens to prevent infection.

Storage Instructions

Store Ozempic in the refrigerator before first use. Afterward, it can be stored at room temperature (59°F to 86°F) or refrigerated (36°F to 46°F) for 56 days. Keep the pen cap on when not in use, and avoid exposure to heat, direct sunlight, and moisture.

What Happens if You Take Too Much Ozempic?

Taking too much Ozempic can lead to severe hypoglycemia (low blood sugar). If this occurs, contact your healthcare provider immediately. Symptoms of low blood sugar include headache, dizziness, confusion, nausea, vomiting, shaking, sweating, weakness, tiredness, hunger, blurred vision, and, in severe cases, seizures.

Treat hypoglycemia promptly by consuming hard candy, crackers, raisins, fruit juice, or non-diet soda. A glucagon injection may be prescribed for severe hypoglycemia.

Ozempic Side Effects

Common side effects include nausea, vomiting, diarrhea, stomach pain, constipation, and weight loss. Rare but serious side effects may include an increased risk of thyroid tumors, inflammation of the pancreas (pancreatitis), very low blood sugar, complications of diabetic retinopathy, gallbladder disease, acute kidney disease, kidney problems, kidney failure, and serious allergic reactions.

  • Common Side Effects
    • Nausea
    • Vomiting
    • Diarrhea
    • Stomach pain
    • Constipation
    • Weight loss
  • Rare but Serious Side Effects
    • Increased risk of thyroid tumors, including cancerous tumors
    • Inflammation of the pancreas (pancreatitis)
    • Very low blood sugar (hypoglycemia)
    • Complications of diabetic retinopathy
    • Gallbladder disease
    • Acute kidney disease, kidney problems, kidney failure
    • Serious allergic reactions (shortness of breath)
  • Monitoring and Reporting:
    • Healthcare providers assess benefits against the risk of side effects
    • Patients encouraged to report negative side effects or adverse reactions to the FDA
    • Contact healthcare provider for guidance and evaluation

Ozempic Drug Interactions

Ozempic can interact with medications such as oral anticoagulants (warfarin), insulin, and other drugs used to treat type 2 diabetes (glyburide, glimepiride, metformin, repaglinide, sulfonylureas). Inform your healthcare provider about all medications and supplements you are taking.

Ozempic Contraindications

Do not use Ozempic if you are allergic to semaglutide, have or have a family history of medullary thyroid carcinoma, have multiple endocrine neoplasia syndrome type 2, have pancreatitis, have type 1 diabetes, or are under 18 years old.

Discuss your medical condition with your doctor if you have had pancreas or kidney problems, diabetic retinopathy, are pregnant or planning to become pregnant, or are breastfeeding.

Ozempic Alternatives

In considering alternatives to Ozempic for managing type 2 diabetes, several FDA-approved options are available. These alternatives cater to diverse patient needs and preferences, providing flexibility in treatment plans. Here’s a breakdown in bullet points:

  • Trulicity (dulaglutide)
    • A GLP-1 receptor agonist
    • Used to treat type 2 diabetes
  • Victoza (liraglutide)
    • Another GLP-1 receptor agonist
    • Treats type 2 diabetes and may help lower blood sugar levels in children with the condition
  • Rybelsus (semaglutide):
    • Different formulation of semaglutide
    • Used with diet and exercise to improve blood sugar in adults with type 2 diabetes
  • Wegovy (semaglutide)
    • FDA-approved for chronic weight management and obesity
    • Utilizes a higher dose of semaglutide


Navigating the world of Ozempic involves understanding its uses, proper dosage, and potential risks. By following prescribed guidelines, staying informed about potential side effects, and promptly addressing any concerns, individuals can ensure a safe and effective journey in managing their diabetes with Ozempic. Always consult your healthcare provider for personalized advice and monitoring.

Written by Amy Fischer

Amy, a registered dietitian at the Good Housekeeping Institute's Nutrition Lab, brings a wealth of expertise to nutrition, health content, and product testing. With a journalism degree from Miami University of Ohio and a master's in clinical nutrition from NYU, she's a versatile expert. Prior to joining Good Housekeeping, Amy worked as a cardiac transplant dietitian at a prominent NYC hospital and contributed to clinical nutrition textbooks. Her background also includes PR and marketing work with food startups.

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